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Development of a O-Conotoxin Analogue with Improved Lipid. – The O-conotoxins MrVIA, MrVIB, and MfVIA inhibit the voltage-gated sodium channel Na V 1.8, a well described target for the treatment of pain; however, little is known about the residues or structural elements that define this activity. In this study, we determined the three-dimensional structure of MfVIA, examined its membrane binding properties, performed alanine-scanning mutagenesis, and.
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The cellular and molecular biology of conifer embryogenesis. – The suspensor has several roles, including the support and positioning of the embryo within the seed, the synthesis of growth regulators, particularly gibberellins, and the conduction of nutrients from the female gametophyte or surrounding cells into the embryo (Yeung & Meinke, 1993; Schwartz et al., 1997).
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Prevalence and Predictors of Early Cardiovascular Events. – Cardiovascular disease remains the leading cause of mortality after renal transplantation. Overall, 47% of deaths without kidney failure in the first month post-transplantation are related to cardiovascular disease[1,2,3,4].
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Development of a O-Conotoxin Analogue with Improved Lipid. – Exposition of the Trp residue to the aqueous environment was examined by Trp fluorescence emission quenching induced by acrylamide, and the membrane depth location of the peptides was examined by a differential fluorescence quenching approach using 5- and 16-doxyl stearic acid (5- and 16-NS) as before .
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